3-O-ETHYL ASCORBIC ACID

The chemical compound 3-ethyl ascorbic acid is a stable vitamin C derivative and is used in cosmetics for its whitening, antioxidant, anti-inflammatory and elasticity-promoting properties. (1,2,3) In one study, an emulsion (O/W) containing 3% ascorbic acid was shown to improve epidermal-dermal microstructure and reduce fine lines and wrinkles after application. (4)

(1) Iliopoulos F, Sil BC, Moore DJ, Lucas RA, Lane ME (2019). 3-O-ethyl-l-ascorbic acid: Characterization and investigation of single solvent systems for delivery to the skin. Int J Pharm X.

(2) Liao WC, Huang YT, Lu LP, Huang WY (2018). Antioxidant Ability and Stability Studies of 3-O-Ethyl Ascorbic Acid, a Cosmetic Tyrosinase Inhibitor. J Cosmet Sci, 69(4), 233-243.

(3) Golonka, I., Oleksy, M., Junka, A., Matera-Witkiewicz, A., Bartoszewicz, M., & Musiał, W. (2017). Selected Physicochemical and Biological Properties of Ethyl Ascorbic Acid Compared to Ascorbic Acid. Biological & pharmaceutical bulletin, 40(8), 1199-1206.

(4) T. Raschke, U. Koop, H.-J. Düsing, A. Filbry, K. Sauermann, S. Jaspers, H. Wenck, K.-P. Wittern (2004). Topical Activity of Ascorbic Acid: From in vitro Optimization to in vivo Efficacy. Skin Pharmacology and Applied Skin Physiology, 17 (4), 200-206.