PALMITOYL PENTAPEPTIDE-4

Palmitoyl pentapeptide-4 is a peptide obtained as a reaction product of palmitic acid and pentapeptide-4. It is also called matrixyl and consists of a short peptide chain with five amino acids (lysine, threonine, threonine, lysine, serine), which is bound to palmitic acid.

Palmitoyl pentapeptide-4 is a biologically active peptide that has been reported to stimulate the production of elastin, fibronectin, glucosaminoglycan and collagens (especially types I, III and IV) and may aid in wound healing.1 It has been shown in studies to be effective in reducing periorbital wrinkles by reducing wrinkle depth and increasing skin barrier function and skin elasticity. (1) (2) (3)

(1) Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.https://doi.org/10.3390/cosmetics4020016

(2) Suhendra, N. N. (2020, August). The efficacy of 7% palmitoyl pentapeptide-4 serum for the periorbital wrinkle reduction. In Rangsit Graduate Research Conference: RGRC (Vol. 15, No. 2563), pp. 2870-2884).

(3) Aruan, R. R., Hutabarat, H., Widodo, A. A., Firdiyono, M. T. C. C., Wirawanty, C., & Fransiska, L. (2023). Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet. The Journal of clinical and aesthetic dermatology, 16(2), 37-43.