PALMITOYL TETRAPEPTIDE-7

Palmitoyl tetrapeptide-7 is a component of certain antibodies with the sequence Pal-Gly-Gln-Pro-Arg.1 Together with palmitoyl tripeptide-1, it is also known as Matrixyl™3000. In studies, Matrixyl™3000 led to a statistically significant reduction in wrinkle length and depth as well as skin roughness and an increase in skin thickness. (1)

Palmitoyl tetrapeptide reduces the release of a proinflammatory signaling protein and thus reduces inflammation after UVB exposure. (2) (3)

(1) Schagen, S. (2017). Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics, 4(2), 16. https://doi.org/10.3390/cosmetics4020016

(2) Resende, D. I. S. P., Ferreira, M. S., Sousa-Lobo, J. M., Sousa, E., & Almeida, I. F. (2021). Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel, Switzerland), 14(8), 702. https://doi.org/10.3390/ph14080702

(3) Mondon, P.; Hillion, M.; Peschard, O.; Andre, N.; Marchand, T.; Doridot, E.; Feuilloley, M.G.; Pionneau, C.; Chardonnet, S. Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: Effect of age and peptide applications. J. Cosmet. Dermatol. 2015, 14, 152-160.