PALMITOYL TRIPEPTIDE-1

Palmitoyl tripeptide-1 is a peptide obtained as a reaction product of palmitic acid and tripeptide-1. Together with palmitoyl tetrapeptide-7, it is also known as Matrixyl™3000 and consists of a short peptide chain with three amino acids (glycine, histidine and lysine = GHK peptide), which is bound to the fatty acid palmitic acid.

Palmitoyl Tripeptide-1 has shown ex vivo the sole ability to boost the synthesis of type 1 collagen in the body and prevent collagen degradation after UVA irradiation. (1) In studies, Matrixyl™3000 has been shown to result in a statistically significant reduction in wrinkle length and depth, skin roughness and increase in skin thickness. (2)

(1) Lintner, K., & Peschard, O. (2000). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International journal of cosmetic science, 22(3), 207-218. https://doi.org/10.1046/j.1467-2494.2000.00010.x

(2) Schagen, S. (2017). Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics, 4(2), 16. https://doi.org/10.3390/cosmetics4020016