PHYTOSPHINGOSINE

Phytosphingosines belong to the sphingolipids, which occur naturally in the stratum corneum both in free form and as part of the main fraction of ceramides. Phytosphingosines are known to strengthen the skin barrier.1 In addition, phytosphingosines have a moisturizing effect by influencing the filaggrin signaling pathway and promote the formation of natural moisturizing factors. (1)Furthermore, phytosphingosines show excellent clinical results in acne skin care based on both anti-inflammatory and antimicrobial activity. (2)(3)

(1) Choi, H. K., Cho, Y. H., Lee, E. O., Kim, J. W., & Park, C. S. (2017). Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation. Archives of dermatological research, 309(10), 795-803. https://doi.org/10.1007/s00403-017-1782-8

(2) Kim, S., Hong, I., Hwang, J. S., Choi, J. K., Rho, H. S., Kim, D. H., Chang, I., Lee, S. H., Lee, M. O., & Hwang, J. S. (2006). Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin. Molecular medicine (Cambridge, Mass.), 12(1-3), 17-24. https://doi.org/10.2119/2006-00001.Kim

(3) Pavicic, T., Wollenweber, U., Farwick, M. and Korting, H.C. (2007), Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. International Journal of Cosmetic Science, 29: 181-190. https://doi.org/10.1111/j.1467-2494.2007.00378.x