BIFIDA FERMENT LYSATE

Bifida Ferment Lysate is a postbiotic and is obtained from the fermentation of the bacterial species Bifidobacterium longum. We use the Repair Complex CLRTM, in this lysate the bacteria are inactivated, but the valuable metabolic products, cytoplasmic fractions, cell wall components and polysaccharide complexes are still present.

The function of this ferment includes the improvement of visible skin redness and skin irritations, as well as the reduction of inflammatory reactions in the skin by decreasing the release of inflammatory mediators. (1)

In addition, experiments show that Bifida Ferment Lysate can statistically significantly improve the expression of numerous barrier genes and antimicrobial peptides in human keratinocytes (skin cells). (2) (3) By strengthening the resistance of the skin barrier, studies have shown that this ferment is able to protect the skin from oxidative stress and inflammatory stimuli. (3)

The skin barrier is crucial for protecting the body from harmful environmental influences. Loricrin is an important protein that is cross-linked during the keratinization of the skin and it plays an essential role in the skin barrier function. Bifida Ferment Lysate led to an increase in the expression of loricrin and other molecules (filaggrin, involucrin, transglutaminase 1) in human skin cells, all of which are important for skin barrier function. (3)

Another important factor for healthy skin is the moisture content. Aquaporin 3 is the most important channel protein in the skin that regulates water content. Bifida Ferment Lysate has been shown to increase aquaporin 3, which leads to an improvement in the skin's moisture content. (3)

In addition, antimicrobial peptides play an important role in the defense against pathogens. These peptides can fight pathogens directly through their antibacterial effect or indirectly via inflammatory pathways. Bifida Ferment Lysate has been associated with increased expression of antimicrobial peptides, such as CAMP and hBD-2, suggesting that it may strengthen the skin's first line of defense against pathogens. (3)

Environmental factors such as UV radiation, visible light and pollution increase the production of reactive oxygen species (ROS) in the skin and can cause oxidative stress. Oxidative stress can disrupt the skin barrier and increase inflammatory reactions. A cutting-edge study showed that Bifida Ferment Lysate is able to efficiently scavenge free radicals and increase antioxidant enzyme activities, which helps to reduce oxidative stress in skin cells. (3)

(1) Guéniche, A., Bastien, P., Ovigne, J. M., Kermici, M., Courchay, G., Chevalier, V., Breton, L., & Castiel-Higounenc, I. (2010). Bifidobacterium longum lysate, a new ingredient for reactive skin. Experimental dermatology, 19(8), e1-e8. https://doi.org/10.1111/j.1600-0625.2009.00932.

(2) Szöllősi, A. G., Gueniche, A., Jammayrac, O., Szabó-Papp, J., Blanchard, C., Vasas, N., Andrási, M., Juhász, I., Breton, L., & Bíró, T. (2017). Bifidobacterium longum extract exerts pro-differentiating effects on human epidermal keratinocytes, in vitro. Experimental dermatology, 26(1), 92-94. https://doi.org/10.1111/exd.13130

(3) Wang, R., Yan, S., Ma, X., Zhao, J., Han, Y., Pan, Y., & Zhao, H. (2023). The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro. Journal of cosmetic dermatology, 10.1111/jocd.15831. Advance online publication. https://doi.org/10.1111/jocd.15831