ACETYL HEXAPEPTIDE-8

Acetyl Hexapeptide-8 is a synthetic peptide and is often used as a neurocosmetic active ingredient. In studies (in vitro), it modulates components of the SNARE complex, which can attenuate mimic micro-contractions - often described as "botox-like" (cosmetic, non-injectable mechanism). (1-2) Application tests report a smoothing of fine lines. In the eye area, additional brightening and soothing effects were observed in the tired-looking eye area. Manufacturer data show that the activity of tyrosinase - a key enzyme in melanin formation - can be inhibited (in vitro) and thus contribute to a more even skin tone. (3-4)

(1) Manufacturer's information

(2) Ruiz Martínez, M. A., Clares Naveros, B., Morales Hernández, M. E., & Gallardo Lara, V. (2010). Evaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide (Argireline®).

(3)Zdrada-Nowak J, Surgiel-Gemza A, Szatkowska M. (2025). Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy. Int J Mol Sci, 26(12), 5722. 

(4) Manufacturer information